A study by Jinyan W et al. indicate that demethylase ALKBH5 was involved in autophagy, hypoxia, and other processes, and its disorder could regulate the occurrence of human tumor20; Tao G et al. demonstrated ALKBH5 can promote tumor progression by enhancing the demethylation in colon cells.21 The gene discussed is ALKBH5; the disease is neoplasm.