Furthermore, increased expression of ICD proteins and higher ICD fold amplitude are commonly associated with the pathology of DCM (Ortega et al., 2017; Perriard et al., 2003; Wilson et al., 2014), so the upregulation of SORBS2 and desmoplakin may be related to the DCM phenotype of MKO mice. This evidence concerns the gene DSP and familial dilated cardiomyopathy.