The essential role of MYPN for normal cardiac function is supported by the identification of an increasing number of heterozygous mutations in the MYPN gene associated with various types of human cardiomyopathy, including hypertrophic (HCM), dilated (DCM), and restrictive (RCM) cardiomyopathy (Bagnall et al., 2010; Duboscq-Bidot et al., 2008; Meyer et al., 2013; Purevjav et al., 2012). Here, MYPN is linked to familial dilated cardiomyopathy.