SORBS2 and familial dilated cardiomyopathy: Furthermore, increased expression of ICD proteins and higher ICD fold amplitude are commonly associated with the pathology of DCM (Ortega et al., 2017; Perriard et al., 2003; Wilson et al., 2014), so the upregulation of SORBS2 and desmoplakin may be related to the DCM phenotype of MKO mice.