Given we found no difference in TxA2‐R expression within lumbar DRG or basal COX metabolites within the skeletal muscle interstitial space between SHAM and HF‐rEF rats, how may we explain the effect of TxA2‐R blockade on the sympathetic and cardiovascular responses to hindlimb muscle contraction (present study) and hindlimb muscle stretch (Butenas, Rollins, et al., 2021)? The gene discussed is TBXA2R; the disease is hydrops fetalis.