PPARA and Alzheimer disease: However, low levels of DHA and eCBs are correlated with AD pathologies in patients and mouse models (Jung et al., 2012; Koppel et al., 2009; Maroof et al., 2014; Schaefer et al., 2006; Soderberg et al., 1991; Yuki et al., 2014), and so is low PPAR activity (Heneka et al., 2005; Pedersen et al., 2006).