Combining unbiased proteome screens in primary neurons and glia with studies in mouse models and AD patient specimens, we uncovered the functional interaction of sortilin with fatty acid-binding protein 7 (FABP7), the intracellular carrier for PUFA and eCBs in the brain (Balendiran et al., 2000; Kaczocha et al., 2009; Xu et al., 1996). The gene discussed is SORT1; the disease is Alzheimer disease.