Interestingly, however, it was reported that IL-4 produced by ILC2s drives Th2 cell differentiation84 and that IL-4 produced by ILC2s in IL-4Rα Y709F mutant mice (Y709 in mice corresponds to Y713 in humans) may promote food allergy by blocking the generation of allergen-specific regulatory T cells91. Here, IL4 is linked to food allergy.