We then compared IRG1 expression in the CD11b+ and CD11b− cells, and our results showed that IRG1 was only highly upregulated in CD11b+ cells isolated from the ipsilateral hemisphere but not in the CD11b− cells isolated from the ipsilateral hemisphere nor in the CD11b+ or CD11b− cells isolated from the contralateral hemisphere of MCAO mice (Fig. 5A, left panel), indicating IRG1 is only upregulated in MG in the injured hemisphere after ischaemic stroke. The gene discussed is ACOD1; the disease is ischemic stroke.