ITGAM and ischemic stroke: We then compared IRG1 expression in the CD11b+ and CD11b− cells, and our results showed that IRG1 was only highly upregulated in CD11b+ cells isolated from the ipsilateral hemisphere but not in the CD11b− cells isolated from the ipsilateral hemisphere nor in the CD11b+ or CD11b− cells isolated from the contralateral hemisphere of MCAO mice (Fig. 5A, left panel), indicating IRG1 is only upregulated in MG in the injured hemisphere after ischaemic stroke.