WDR45B and neurodevelopmental disorder: ,5 Biallelic variants in WIPI3 (WDR45B, OMIM #609226) cause a syndrome known as a neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures (NEDSBAS, OMIM #617977), characterized by progressive neurological deterioration with pyramidal and extrapyramidal features as well as musculoskeletal abnormalities.6