It may also regulate VEGFA, IL6, ERK1/2 (MAPK1/MAPK3), AKT1, MYC, CDKN1A, NF-KB, and other genes to effectively against SLE-ONFH because they have an important position in the gene-pathway network; this requires further research in the future, and we will continue to explore their roles in the process in SLE-ONFH. This evidence concerns the gene AKT1 and systemic lupus erythematosus.