IRX3 is a functional long-range target of obesity-associated variants within FTO, IRX3-deficient mice reduces body weight by reducing fat mass and increasing basal metabolic rate and browning of white adipose tissue (20), and EBF2 promotes the recruitment of beige adipocytes in white adipose tissue and protects animals against obesity (21). This evidence concerns the gene EBF2 and obesity due to melanocortin 4 receptor deficiency.