The polymorphism of several other genes, including glucokinase regulator (GCKR), membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and hydroxysteroid 17β-dehydrogenase (HSD17B13), are closely associated with susceptibility to NAFL and progression of NASH (53). The gene discussed is GCKR; the disease is metabolic dysfunction-associated steatohepatitis.