In the present study, we have shown: (1) patients with CAD exhibited lower plasma BDNF levels and higher soluble P-selectin levels than their non-CAD counterparts, despite the use of antiplatelet therapy; (2) soluble P-selectin levels were correlated with plasma BDNF levels, an association that was significantly influenced by the presence of CAD, and (3) plasma BDNF was a reverse mediator in the negative relationship between platelet activation and cognitive function. This evidence concerns the gene SELP and coronary artery disorder.