Multivariable analysis showed that higher VAP-1 levels were associated with an increased risk of CV events both in patients with (HR, 2.39; 95% CI, 1.14–5.03; P = 0.022) and without (HR, 2.57; 95% CI, 1.05–6.30; P = 0.039) diabetes mellitus. This evidence concerns the gene AOC3 and diabetes mellitus.