These signals can be activators (TLR 2, 4, 6; IL-1R, IFNγR, and TNFR), generally induced during conditions of poor nutrition, infections, use of antibiotics, pollution, smoking, or limitation of the microbiota; or suppressors (CD200R, SIRPα, mannose receptor, TREM2, IL-10R, and TGFβR) that are related to homeostasis and induced during conditions of balanced diet, minimal infections, limited antibiotic usage, or diverse microbiota (23). This evidence concerns the gene TNFRSF1A and infection.