It was also reported in patients with pulmonary emphysema that the peripheral capacity of these cells was normal both in patients with emphysema and in control subjects, however, secretion of IL-10 by Tregs cells from the entire lung of patients with emphysema was impaired, suggesting that the inflammatory medium affects the activation and function of Tregs cells in local tissues (33). The gene discussed is IL10; the disease is pulmonary emphysema.