The risk assessment in patients with LC demonstrated that when the median was considered the cutoff point in the two-group classification, the adjusted OR values of ADA, AFU, and LAC for the risk of developing LC among patients in the high-level group compared to those in the low-level group were 3.218, 1.859, and 11.474, respectively. This evidence concerns the gene ADA and laryngotracheoesophageal cleft.