CXCL8 and acquired epidermolysis bullosa: Based on the current understanding of autoantibody-induced tissue pathology in the inflammatory variant of EBA (12, 21), where neutrophils migrate form the blood into the skin, form an immunological synapse by binding to the immune complexes located at the dermal-epidermal junction, and ultimately release ROS, we evaluated the impact of the PI3Ki on (i) IL-8-induced neutrophil migration, (ii) IC-induced neutrophil spreading, and (iii) IC-induced ROS release form neutrophils.