Combining several databases, our study found that the mRNA levels of B3GAT3, B4GALT2, CYB5R3, GNPDA1, HEXB, PLOD2, and SEPHS1 were increased in HCC tissues while mRNA levels of GOT2 and HMGCS2 were decreased in HCC tissues. The gene discussed is B4GALT2; the disease is hepatocellular carcinoma.