Additionally, the 5hmCH-enriched genes of BE(2)-C, such as collagens (COL5A1, COL13A1, COL23A1), cytoskeletal proteins (MYH9, PLEC) (Piskareva et al., 2015), TGFβ, and SHH signaling pathway members (TGFB1, GLI2) (Shao et al., 2017) could contribute to EMT induction and tumor invasiveness. Here, COL5A1 is linked to neoplasm.