Additionally, the 5hmCH-enriched genes of BE(2)-C, such as collagens (COL5A1, COL13A1, COL23A1), cytoskeletal proteins (MYH9, PLEC) (Piskareva et al., 2015), TGFβ, and SHH signaling pathway members (TGFB1, GLI2) (Shao et al., 2017) could contribute to EMT induction and tumor invasiveness. This evidence concerns the gene SHH and neoplasm.