Attenuated colitis was described in both NLRP3-deficient mice (Bauer et al., 2012) and after selective blockade of NLRP3 (Perera et al., 2018) in different animal models of intestinal inflammation, whereas inflammatory progression associated with altered intestinal integrity and increased mortality have also been outlined in NLRP3 knockout mice with experimental colitis (Zaki et al., 2010). This evidence concerns the gene NLRP3 and colitis.