However, in an already established tumor, the maturation of myeloid cells to macrophages is blocked by multiple factors and mechanisms, such as tumor-derived growth factors (STAT3, IRF8, C/EBPβ, Notch, adenosine receptors A2B signaling, NLRP3), hypoxia, and negative feedback loops (1, 80). This evidence concerns the gene NLRP3 and neoplasm.