As for the molecular features, most frequently altered genes in localized DLBCL included PIM1, TET2, KMT2D, BTG2, BTG1, MYD88, ARID1A, HIST1H1E, MPEG1, TNFAIP3, TP53, CREBBP, FAS, GNA13, and TMSB4X, which were also reported to be commonly mutated in DLBCL (27, 28). This evidence concerns the gene H1-4 and diffuse large B-cell lymphoma.