ASK1: apoptosis signal-regulating kinase 1; FXR: farnesoid X receptor; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; F3, STELLAR III: patients with NASH and bridging fibrosis; F4, STELLAR IV: patients with compensated cirrhosis. The gene discussed is MAP3K5; the disease is metabolic dysfunction-associated steatohepatitis.