Previous studies reported lncRNAs HOTAIR (Lee et al., 2016; Niinuma et al., 2012), H19 (Badalamenti et al., 2019) and AOC4P (Hu et al., 2018) are associated with the onset and progression of gastric GISTs and drive malignant character in GIST. This evidence concerns the gene H19 and gastrointestinal stromal tumor.