Previous studies reported lncRNAs HOTAIR (Lee et al., 2016; Niinuma et al., 2012), H19 (Badalamenti et al., 2019) and AOC4P (Hu et al., 2018) are associated with the onset and progression of gastric GISTs and drive malignant character in GIST. The gene discussed is AOC4P; the disease is gastrointestinal stromal tumor.