Cases of AML with chromosomal rearrangements as t(15;17) [PML-RARA], t(9;22) [BCR-ABL], inv(16) [CBFB-MYH11], t(8;21) [RUNX1-ETO] are called cytogenetically abnormal (CA-AML), while cases with genetic abnormalities (including frequent mutations inDNMT3A,NPM1,CEBPα,IDH1/2, TET2, FLT3-ITD) are called cytogenetically normal (CN-AML)1,4. The gene discussed is MYH11; the disease is acute myeloid leukemia.