Butanoate metabolism-related proteins were significantly increased in ovarian cancers relative to controls (fold change > 1.5), including EHHADH (fold change = 1.62, p = 2.25E − 3), ECHS1 (fold change = 1.52, p = 3.56E − 3), BDH1 (fold change = 1.54, p = 3.00E − 3), and HMGCS2 (fold change = 2.17, p = 2.10E − 3). This evidence concerns the gene HMGCS2 and ovarian carcinoma.