BECN1 and Alzheimer disease: Alkaloids isolated from Dendrobium nobile enhanced autophagic flux via autophagosome generation and stimulated Beclin-1 expression [101], and berberine has been reported to stimulate autophagy by activating Bcl2/Beclin-1 signaling, thus increasing Aβ clearance, and to improve cognitive functions in a mouse model of AD [102].