Given the link between the deficient variants of the SERPINA1 gene and pediatric intrahepatic cholestasis as a manifestation of AATD (Chen et al., 2018; Comba et al., 2018; Lin et al., 2019), we aimed to assess the presence and frequency of the two most common SERPINA1 nucleotide variants – PI*Z and PI*S – in a group of 103 women with a history of ICP. This evidence concerns the gene SERPINA1 and intrahepatic cholestasis.