ZBTB21 and hepatocellular carcinoma: Furthermore, we identified miRNAs that target other epi-machinery genes as well, such as DNA demethylase TET2 and methyl-CpG-binding proteins, ZBTB12 and ZBTB21. In addition, histone methylases and demethylases were found to be targets of differentially expressed miRNAs in HCC from this analysis, providing another role for the epigenetic regulation of HCC, which may be a topic of interest for future targeted analyses (Supplementary Table 3).