zDHHC3 palmitoylates and stabilizes PD-L1 in human colorectal cancer (CRC) cells by blocking PD-L1 ubiquitination thereby inhibiting endosomal sorting complexes required for transport (ESCRT)-mediated multivesicular body (MVB) sorting and lysosomal degradation, which results in elevated cell surface expression of PD-L1. This evidence concerns the gene CD274 and colorectal cancer.