TREX1 and systemic lupus erythematosus: Aberrant activation of the STING pathway has been implicated in the pathogenesis of a variety of inflammatory and autoimmune diseases including Aicardi–Goutières syndrome (ASG) and systemic lupus erythematosus (SLE) (186–188), which are both caused by loss of function mutations in the enzyme 3’ repair exonuclease I (TREX1) gene.