MAPT and amyloidosis: Based on spatiotemporal analysis of multi-modal imaging data (i.e., PET, MRI, etc.), the pTIF demonstrates that the patients may need different treatments, not only depending on their brain's unifactorial alterations (e.g., tau and amyloid accumulation or not, dopamine alteration or not, atrophy or not) but also on their individual multifactorial brain dynamics: how the different biological factors interact and how they would respond (at the individual level) to potential clinical perturbations.