CXCL8 and systemic lupus erythematosus: IPA showed that some immune-relevant pathways were activated, including acute phase response signaling, complement system, and the role of pattern recognition receptors, such as in recognition of bacteria and viruses, leukocyte extravasation signaling, dendritic cell maturation, systemic lupus erythematosus in B cell signaling pathway, interleukin-8 signaling, and the Th1 and Th2 pathways.