As shown in Figures 7A,B, administration of QCWZD expedited ISCs proliferation, as evidenced by significant compensated the expressions of stem cell markers such as Lgr5 and achaete-scute like-2 (Ascl2) in colon of colitis mice in the present of QCWZD when compared to mice in DSS group. Here, ASCL2 is linked to colitis.