TEK and pulmonary fibrosis: Tie2-driven conditional deletion of Twist1 in the endothelium was also shown to be associated with reduction of lung fibrosis (Mammoto et al., 2013; Mammoto et al., 2016; Mammoto et al., 2018), while Tie2-driven deletion of Snail led to embryonic lethal vascular defects (Wu et al., 2014).