Despite lack of mutations in growth factor receptors and other receptor tyrosine kinases (RTKs), except ALK (mutated in 9% of all NB), which has a strong correlation with MYCN-amplification [6], several studies showed that NBs are highly dependent on RTK signaling, such as KIT [7, 8], PDGFRB [8], MET [9], and RET [9, 10]. This evidence concerns the gene MYCN and neuroblastoma.