EPHX2 and Mental deterioration: Our primary hypothesis was that cognitive decline is associated with an abrogation of normal epoxy fatty acid status based on findings that inhibition of soluble epoxide hydrolase, an enzyme previously implicated in the regulation of microvascular tone and inflammation, protects hippocampal neuronal death and reduces cognitive decline in mice7, and that genetic deletion of this enzyme slows amyloid beta associated Alzheimer’s disease onset in mice8.