HIF1A and neoplasm: While some background EpCAM staining was detected in non-tumor-bearing (PyMT−) bone marrow (Supplementary Fig. 2), a significant decrease in the number of EpCAM+ cells was detected in the bone marrow from Hif1α−/− PyMT+ mice compared to Hif1αf/f PyMT+ mice when normalized to total tumor weight at end point (Fig. 3a and Supplementary Fig. 3a).