EPAS1 and neoplasm: While microCT analysis of Hif2α−/− PyMT+ mice did not reveal any differences in trabecular bone parameters (Supplementary Fig. 5h–l), flow cytometric analysis of hindlimb bone marrow from Hif2α−/− PyMT+ mice revealed a significant reduction in the percentage of EpCAM+ tumor cells (Fig. 5a).