We observed no difference between the Hif2αf/f PyMT+ and Hif2α−/− PyMT+ mice in the time it took tumors to reach collection size (Supplementary Fig. 5a, b), the total tumor weight upon sacrifice (Supplementary Fig. 5c), or the number of tumors (Supplementary Fig. 5d). This evidence concerns the gene EPAS1 and neoplasm.