Furthermore, the development of insulin resistance in obese animal reduced sensitivity of metabolic tissues including adipose tissue to insulin action as revealed by QUICKI, this possibly increased lipolysis with corresponding increase in circulating lipids such as TG/HDLc and TC/HDLc resulting in excess lipid influx into the non-metabolic tissues, including hypothalamic tissue with correspondent elevated TG and TC compared to the control group. The gene discussed is INS; the disease is Insulin resistance.