AFP and cancer: The findings showed that T classification (P = 0.0032), stage (P < 0.001), grade (P = 0.0175), family cancer history (P = 0.0359), AFP level (P = 0.0147), cancer status (P < 0.001), recurrence event (P < 0.001) and patient status were significantly correlated with HCC risk groups in the TCGA discovery cohort (P < 0.001).