AFP and cancer: In addition, KM survival analysis revealed that disease-specific survival rates were significantly different in some pathological subgroups, such as T classification (T1–2 vs T3-4, P < 0.001), stage (Stage I–II vs III–IV, P < 0.001), cancer status (Tumor Free vs With Tumor, P = 0.011), hepatitis virus infection (HVI Negative vs Positive, P = 0.008), Child–Pugh Score (A/B vs C, P < 0.001) and AFP (≤ 200 vs > 200, P = 0.002) for TCGA OS (Figure S4).