CYP1B1 and cancer: To corroborate these findings, we performed an in silico analysis of the RNA data from Cancer Cell Line Encyclopaedia (CCLE) dataset for HNC cell lines using the public cBioPortal website39 and found that the isoforms CYP1B1 and CYP2W1 were amplified in Detroit-562 and SCC4 respectively (Fig. S1).