After accounting for the effect of other influences, we found that recent-onset-OBs had significantly higher values of WC (+ 16.1 cm), SBP (+ 7 mmHg), DBP (+ 5 mmHg), insulin (+ 4.3 uUI/dl), HOMA-IR (+ 0.97) TG (+ 14.0 mg/dL), hs-CRP (+ 0.89 mg/l), and MetS zscore (+ 0.05 SD), and lower values of HDL-chol (− 2.9 mg/dl) and adiponectin (− 1.05 μg/ml) than never-OBs. The gene discussed is INS; the disease is metabolic syndrome.