Compared to 9p21-WT tumors, 9p21-loss tumors demonstrated a significant decrease in a number of immune-related pathways including antigen processing and presentation, BCR/TCR signaling, interferon alpha/beta/gamma-mediated immune response, CTLs pathway, and such changes were ubiquitous in 9 out of 12 examined cohorts, with exception of GBM, LGG, and ESCA (Supplementary Fig. 15 and Supplementary Data 8). This evidence concerns the gene BCR and glioblastoma.