For example, we analyzed myeloid DC subsets including plasmacytoid dendritic cells (pDCs), LAMP3 + DCs, cDC1, and cDC230 and observed an overall decrease in all DC subsets in 9p21-loss tumors, except the cDC2 population, which was enriched in the esophageal squamous-cell carcinoma (ESCA_ESCC) and EGFR-mutant LUAD with 9p21 loss (Supplementary Fig. 10a). This evidence concerns the gene MPPE1 and esophageal squamous cell carcinoma.