We also observed a trend towards decreased proportion of the “non-brisk focal” pattern (with TILs scattered throughout <5% but >1% of the area of the tumor) in SKCM with BRAF hotspot mutations (Supplementary Fig. 7), and increased proportion of the “brisk band-like” pattern (with TILs mostly localized to the invasive margin of the tumor without entering the tumor body) in 9p21-loss LUAD with somatic EGFR or STK11 mutations (Supplementary Fig. 7). Here, EGFR is linked to neoplasm.