Consistently across most (10/12) cancer types with frequent 9p21 loss (versus 9p21-WT tumors), we observed remarkable decrease in abundance of B cells, T cells, NK cells, T follicular helper cells, memory CD4 T cells, CD8 T-cells, and cytotoxic lymphocytes revealed by both MCP-counter and CIBERSORTx, and such changes remained significant in stratified analysis based on previously defined molecular subtypes (Fig. 2c, d, Supplementary Fig. 8 and Supplementary Data 6). The gene discussed is CD4; the disease is cancer.