CD274 and non-small cell lung carcinoma: A composite of PD-L1 expression and TMB showed improved but suboptimal performance in identifying patients (e.g., with non-small cell lung cancer, NSCLC) who could achieve durable clinical benefit and was not sufficient to identify patients that are most likely fail to respond to (or derive no benefit from) ICT17, highlighting the need for more robust approaches for identifying new biomarkers.