CD274 and neoplasm: We demonstrate that 9p21-loss tumors were immunologically “cold”, exhibiting much lower densities of TILs, reduced abundance of tumor-infiltrating immune cells of both the adaptive (e.g. B and T cells) and innate (e.g. NK cells) immune systems, altered spatial TILs patterns, shifted immune cell compositions, impaired TCR, antigen presentation, interferon signaling, and a lower rate of PD-L1 positivity.