Remarkably, after adjusting for all available tumor-pathological factors in multivariable models (Table 2), high CYP27A1 expression was independently and strongly prognostic for longer DRFS (HRadj = 0.26, 95% CI = 0.10–0.72) for all patients and for the subset of patients with ER+ tumors, DRFS (HRadj = 0.13, 95% CI = 0.03–0.60). This evidence concerns the gene ESR1 and neoplasm.