To characterize the pathways that are targeted by APA in lung cancer, we performed a pathway enrichment analysis using IPA32 and found those mRNA transcripts with shorter 3′UTRs were enriched with cell cycle/proliferation pathways often dysregulated in cancer, including mTOR and its target ubiquitin proteolysis pathway, receptor tyrosine kinase signaling and signaling specific to lung cancer. This evidence concerns the gene MTOR and lung cancer.