Given our observation of increased glycolysis in MYCHigh samples, we confirmed MYC expression and the upregulation of the glycolysis proteins HK2, PFKFB3, and LDHA (Fig. 2a) in a panel of MYCHigh (H446, H82, H524) human SCLC cell lines in comparison to MYCLow (H1522, H1092, DMS79) cell lines (Fig. 2b). This evidence concerns the gene PFKFB3 and small cell lung carcinoma.