Given our observation of increased glycolysis in MYCHigh samples, we confirmed MYC expression and the upregulation of the glycolysis proteins HK2, PFKFB3, and LDHA (Fig. 2a) in a panel of MYCHigh (H446, H82, H524) human SCLC cell lines in comparison to MYCLow (H1522, H1092, DMS79) cell lines (Fig. 2b). Here, MYC is linked to small cell lung carcinoma.