CALCA and Alzheimer disease: Among the 20 drugs discovered, 7 drugs (Calcitonin, Wortmannin, Gentamicin, Tacrolimus, Progesterone, Gentamicin, and Hyaluronan) have been reported to have certain experimental and clinical benefit for the treatment of AD. This shows that our GEO cohort based on big data the analysis has certain value for the potential treatment of AD.