By employing a sequence of bioinformatics tools for gene expression profiling, we established the core function of key candidate genes, including ITGB1, SPP1, CD44, THY1, CCL5, and BMP7, and the enriched signaling cascades constituting the ECM-receptor interaction pathways in the molecular modulation network of cognitive decline via integrated bioinformatic analysis. This evidence concerns the gene CCL5 and Mental deterioration.