Consistent with the analysis results from HPA, our IHC staining result of 20 samples (7 high grade glioma tissues, 7 low grade glioma tissues, and 6 normal brain tissues) also verified the protein expression of GINS4 was significantly increased in glioma, and the level of GINS4 protein was positively correlated with the grade of glioma (Fig. 2). Here, GINS4 is linked to central nervous system cancer.