Based on the results of previous studies and this study, we have more reason to believe that GINS4 plays an indispensable role in glioma, and it may play a role in the malignant process of glioma together with RFWD3, BUB1, CDK2, CENPL, ESCO2, and CLSPN. Thus, the results of co-expression analysis of GINS4 bring new insight to gliomagenesis. Here, ESCO2 is linked to central nervous system cancer.