Hence, the above results demonstrated that GINS4 was implicated in the tumor immune microenvironment mainly through the regulation of Dendritic cell function and Immune checkpoint (CD274, PDCD1, and PDCD1LG2), and GINS4 may affect the survival rate of patients by affecting the tumor immune microenvironment in glioma. Here, PDCD1LG2 is linked to glioma.