TP53 and central nervous system cancer: In recent years, with the development of molecular pathology, several molecular markers have been confirmed to be associated with glioma, which acts a vital guiding role in the clinical treatment of glioma, such as epidermal growth factor receptor (EGFR), O-6-methylguanine-DNA methyltransferase (MGMT), tumor protein p53 (TP53), Isocitrate dehydrogenase (IDH mutation) and 1p/19q codeletion (Melin and Jenkins 2013; Gupta and Salunke 2012; Jones et al. 2013; Riemenschneider et al. 2010).