Moreover, the analysis of the profile evolution of CD8+ T cells in several infections shows that exhaustion in the sense of a dysfunctional phenotype occurs during the acute phase of C-13 LCMV infection, but not in other infections such as influenza, vesicular stomatitis virus (VSV) or Listeria monocytogenes [28], and HBV [49]. The gene discussed is CD8A; the disease is infection.