We found that when cup-2 was knocked down by RNAi in rrf-1(pk1417); puf-8(q725); glp-1(oz264gf) animals, 63% of animals contained complete tumours as compared to 97% in the gfp(RNAi) negative control animals (Fig 6A and Table 4). The gene discussed is GLP1R; the disease is neoplasm.