GLP1R and neoplasm: Moreover, while loss of cup-2 suppresses the complete tumour phenotype from 100% tumourous gonads in puf-8(q725); glp-1(ar202gf) double mutants to 92% tumourous animals in cup-2(tm2838); puf-8(q725); glp-1(ar202) triple mutants, also eliminating der-2 function in cup-2(tm2838); puf-8(q725); der-2(tm6098) glp-1(ar202) quadruple mutants significantly reduces the percentage of completely tumourous animals to 67% (Fig 1B and Table 1).