Contrary to SLE neutrophils, healthy neutrophils produced IL-33 NETs only after priming with exogenous recombinant IFN-α followed by administration of ICs (Supplemental Figure 4B) (13, 14), which reiterates the role of the SLE milieu in determining the neutrophil NETotic potential. Here, IFNA1 is linked to systemic lupus erythematosus.