Contrary to SLE neutrophils, healthy neutrophils produced IL-33 NETs only after priming with exogenous recombinant IFN-α followed by administration of ICs (Supplemental Figure 4B) (13, 14), which reiterates the role of the SLE milieu in determining the neutrophil NETotic potential. The gene discussed is IL33; the disease is systemic lupus erythematosus.