Importantly, all 3 IL-33 peptides found to be upregulated in SLE IC NETs were localized near the C-terminus, which exists in the bioactive isoforms of IL-33 and accounts for their signaling potential (17, 18), and not in the N-terminus, which is found only in the full-length protein (Figure 6C). The gene discussed is IL33; the disease is systemic lupus erythematosus.