IL33 and systemic lupus erythematosus: Furthermore, when comparing NOX-dependent (namely, phorbol 12-myristate 13-acetate–treated [PMA-treated] healthy neutrophils) versus NOX-independent (namely, monosodium urate–treated [MSU-treated] healthy neutrophils, IC-treated SLE neutrophils) NETs, only the latter exhibited significant IL-33 decoration (Supplemental Figure 3B), thus suggesting a mechanistic link between NOX-independent pathway of NETosis and IL-33 release.