DES and cardiomyopathy: In support of this, age‐related cardiomyopathy is recapitulated in adult mice by cardiac‐specific Atg5 deletion (Taneike et al., 2010) and mTORC1 activation (Li et al., 2017; Taneike et al., 2016), whereas desmin‐related cardiomyopathy, characterized by the accumulation of cytotoxic misfolded proteins, is prevented by cardiac‐selective Atg7 overexpression (Bhuiyan et al., 2013).