DES and cardiomyopathy: In this regard, He et al. observed that an acute bout of treadmill running elevates protein indexes of autophagy in murine hearts (He et al., 2012), and Bhuiyan et al. reported that autophagy, protein clearance, and function improved in hearts from mice with desmin‐related cardiomyopathy that did vs. did not have long‐term access (i.e., 6‐month) to wheel running (Bhuiyan et al., 2013).