While all members of the TNF superfamily, consisting of 19 ligands and 29 receptors [44], have been suggested to be involved in a variety of cellular events including proliferation, differentiation and apoptosis, the B-cell activating factor of TNF family (BAFF) has recently gained extra attention due to its major role in regulating the tumor microenvironment including induction of apoptosis [45, 46]. The gene discussed is TNF; the disease is neoplasm.